With the Flash under his control, Bloodwork attacks Central City and converts most of its citizens into his "Blood Brothers and Sisters". Cisco and Iris argue over how to save Barry and stop Bloodwork, but both of their plans fail. However, Bloodwork chooses not to convert them in favor of enacting the final phase of his plan; taking the Particle Accelerator to spread his blood across all of Central City. As he makes his way inside, Cisco and Iris realize that during their last encounter, Barry used his connection to Bloodwork to save them and secretly tell them how to beat him. Using a combination of Bloodwork's blood, the particle accelerator, and Allegra's powers, Team Flash subvert Bloodwork's plan and cure Central City of his influence. With his plan foiled, Bloodwork transforms into a monster to kill the Flash and begin anew, only to be distracted by a hallucination of his mother long enough for the speedster to trap him in Runk's prison. With Bloodwork remanded to A.R.G.U.S.'s custody, Team Flash spend their last moments before Crisis together just as red skies loom over them. Meanwhile, Nash uncovers a wall of symbols before a blinding light pulls him inside.